LRMP Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Belongs to the LRMP family. Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of mouse Ortholog: 6 G3|6 77.34 cM
Cellular Component:  chromosome; cytoplasm; cytoskeleton; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane; nucleus
Molecular Function:  protein binding
Biological Process:  immune system process; single fertilization
Reference #:  Q60664 (UniProtKB)
Alt. Names/Synonyms: AI553456; D6In; D6Int3; D6Int4; D6Int5; D6Int7; D6Int8; Inositol 1,4,5-triphosphate receptor associated 2; IRAG2; Jaw; Jaw1; Lrmp; Lymphoid-restricted membrane protein; OTTMUSP00000028617; Processed inositol 1,4,5-triphosphate receptor associated 2; Processed lymphoid-restricted membrane protein; Protein Jaw1
Gene Symbols: Lrmp
Molecular weight: 59,588 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene