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LPPR4
Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. Belongs to the PA-phosphatase related phosphoesterase family. Specifically expressed in neurons. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; EC 3.1.3.4; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Phosphatase, lipid |
| Chromosomal Location of mouse Ortholog: 3 G1|3 50.57 cM |
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Cellular Component:
external side of plasma membrane; glutamatergic synapse; membrane; plasma membrane; postsynaptic density membrane; postsynaptic membrane; synapse
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Molecular Function:
lipid phosphatase activity; lysophosphatidic acid phosphatase activity; phosphatidate phosphatase activity; protein binding
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Biological Process:
axonogenesis; G protein-coupled receptor signaling pathway; inner ear development; lipid import into cell; modulation of chemical synaptic transmission; phospholipid dephosphorylation; phospholipid metabolic process; regulation of synaptic transmission, glutamatergic; signal transduction
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Reference #:
Q7TME0
(UniProtKB)
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Alt. Names/Synonyms: A330086D10; Brain-specific phosphatidic acid phosphatase-like protein 1; D3Bwg0562e; DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed; Kiaa0455; Lipid phosphate phosphatase-related protein type 4; Lppr4; mKIAA0455; OTTMUSP00000028305; phospholipid phosphatase related 4; Phospholipid phosphatase-related protein type 4; Php1; plasticity related gene 1; Plasticity-related gene 1 protein; Plppr4; PLPR4; PRG; PRG-1; Prg1
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Gene Symbols: Plppr4
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Molecular weight:
83,290 Da
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Basal Isoelectric point:
9.07
Predict pI for various phosphorylation states
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