KIF22 Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of mouse Ortholog: 7 F3|7 69.29 cM
Cellular Component:  chromatin; cytoplasm; cytoskeleton; cytosol; kinesin complex; microtubule; mitotic spindle; nuclear speck; nucleus; spindle
Molecular Function:  ATP binding; ATP hydrolysis activity; DNA binding; microtubule binding; microtubule motor activity; nucleotide binding
Biological Process:  DNA repair; metaphase plate congression; microtubule-based movement; mitotic metaphase plate congression; sister chromatid cohesion
Reference #:  Q3V300 (UniProtKB)
Alt. Names/Synonyms: AU021460; C81217; Kid; Kif2; Kif22; Kif22a; kinesin family member 22; kinesin family member 22A; Kinesin-like protein KIF22
Gene Symbols: Kif22
Molecular weight: 73,190 Da
Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein