KI-67 Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nucleolus
Chromosomal Location of Human Ortholog: 7|7 F3
Cellular Component:  chromosome; chromosome, centromeric region; condensed chromosome; cytoplasm; nuclear body; nucleolus; nucleus
Molecular Function:  ATP binding; DNA binding; nucleotide binding; protein C-terminus binding
Biological Process:  cell cycle; cell proliferation; cholangiocyte proliferation; hepatocyte proliferation; meiotic cell cycle; regulation of chromatin organization; regulation of chromosome segregation; regulation of mitotic nuclear division
Reference #:  E9PVX6 (UniProtKB)
Alt. Names/Synonyms: antigen identified by monoclonal antibody Ki 67; D630048A14Rik; Ki-67; Ki-67 protein; Ki67; Mki67; Proliferation marker protein Ki-67
Gene Symbols: Mki67
Molecular weight: 350,864 Da
Basal Isoelectric point: 9.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein