Kv7.5 Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1|1 A4
Cellular Component:  clathrin coat; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  calmodulin binding; delayed rectifier potassium channel activity; ion channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process:  ion transport; potassium ion transmembrane transport; potassium ion transport; regulation of ion transmembrane transport; transmembrane transport
Reference #:  Q9JK45 (UniProtKB)
Alt. Names/Synonyms: 7730402H11; 9230107O05Rik; AA589396; D1Mgi1; Kcnq5; KQT-like 5; OTTMUSP00000021275; Potassium channel subunit alpha KvLQT5; Potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, subfamily Q, member 5; Voltage-gated potassium channel subunit Kv7.5; voltage-gated potassium channel type Kv7.5
Gene Symbols: Kcnq5
Molecular weight: 102,258 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene