H1E Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  chromosome; nuclear nucleosome; nucleolus; nucleosome; nucleus
Molecular Function:  ADP binding; AMP binding; ATP binding; calcium ion binding; dATP binding; DNA binding; double-stranded DNA binding; GTP binding; nucleotide binding; protein binding
Biological Process:  histone H3-K27 trimethylation; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; nucleosome positioning; regulation of transcription from RNA polymerase II promoter
Reference #:  P43274 (UniProtKB)
Alt. Names/Synonyms: H1 histone family, member 4; H1 VAR.2; H1-4; H14; H1e; H1f4; H1s-4; H1var2; Hist1h1e; histone 1, H1e; histone cluster 1, H1e; Histone H1.4; histone H1e; OTTMUSP00000000532
Gene Symbols: Hist1h1e
Molecular weight: 21,977 Da
Basal Isoelectric point: 11.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene