H1E Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  chromosome; nuclear chromatin; nuclear euchromatin; nuclear nucleosome; nucleosome; nucleus
Molecular Function:  ADP binding; AMP binding; ATP binding; calcium ion binding; dATP binding; DNA binding; double-stranded DNA binding; GTP binding; nucleosomal DNA binding; nucleotide binding; protein binding
Biological Process:  chromosome condensation; histone H3-K27 trimethylation; histone H3-K4 trimethylation; negative regulation of chromatin silencing; negative regulation of DNA recombination; negative regulation of transcription by RNA polymerase II; nucleosome assembly; nucleosome positioning; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  P43274 (UniProtKB)
Alt. Names/Synonyms: H1 histone family, member 4; H1 VAR.2; H1-4; H1.4; H1.4 linker histone, cluster member; H14; H1e; H1f4; H1s-; H1s-4; H1v; H1var2; Hist1h; Hist1h1e; histone 1, H1e; histone cluster 1, H1e; Histone H1.4; histone H1e; OTTMUSP00000000532
Gene Symbols: Hist1h1e
Molecular weight: 21,977 Da
Basal Isoelectric point: 11.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene