UGT1A4 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. Belongs to the UDP-glycosyltransferase family. Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 2 but not isoform 1 is expressed in esophagus. Not expressed in skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of mouse Ortholog: 1|1 D
Cellular Component:  endoplasmic reticulum; intracellular membrane-bounded organelle
Molecular Function:  enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; UDP-glycosyltransferase activity
Biological Process:  cellular glucuronidation; flavonoid glucuronidation; xenobiotic glucuronidation
Reference #:  Q6XL48 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000022775; UDP glucuronosyltransferase 1 family, polypeptide A5; UDP glycosyltransferase 1 family polypeptide A5; UDP glycosyltransferase 1 family, polypeptide A5; UDP-glucuronosyltransferase; UGT1A4; Ugt1a5
Gene Symbols: Ugt1a5
Molecular weight: 60,041 Da
Basal Isoelectric point: 8.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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UGT1A4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene