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UGT1A4
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. Belongs to the UDP-glycosyltransferase family. Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 2 but not isoform 1 is expressed in esophagus. Not expressed in skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 |
| Chromosomal Location of mouse Ortholog: 1|1 D |
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Cellular Component:
endoplasmic reticulum; intracellular membrane-bounded organelle
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Molecular Function:
enzyme binding; glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; UDP-glycosyltransferase activity
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Biological Process:
cellular glucuronidation; flavonoid glucuronidation; xenobiotic glucuronidation
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Reference #:
Q6XL48
(UniProtKB)
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Alt. Names/Synonyms: OTTMUSP00000022775; UDP glucuronosyltransferase 1 family, polypeptide A5; UDP glycosyltransferase 1 family polypeptide A5; UDP glycosyltransferase 1 family, polypeptide A5; UDP-glucuronosyltransferase; UGT1A4; Ugt1a5
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Gene Symbols: Ugt1a5
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Molecular weight:
60,041 Da
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Basal Isoelectric point:
8.33
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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