EAF1 Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Belongs to the EAF family. Strongly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine and colon. Poorly expressed in thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 14|14 B
Cellular Component:  ELL-EAF complex; intercellular bridge; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; nucleus; transcription elongation factor complex
Molecular Function:  transcription factor binding
Biological Process:  positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q9D4C5 (UniProtKB)
Alt. Names/Synonyms: 4933403C17Rik; AI666536; Eaf1; ELL associated factor 1; ELL-associated factor 1
Gene Symbols: Eaf1
Molecular weight: 28,967 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene