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EAF1
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Belongs to the EAF family. Strongly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine and colon. Poorly expressed in thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of Human Ortholog: 14|14 B |
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Cellular Component:
ELL-EAF complex; intercellular bridge; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; nucleus; transcription elongation factor complex
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Molecular Function:
transcription factor binding
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Biological Process:
positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
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Reference #:
Q9D4C5
(UniProtKB)
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Alt. Names/Synonyms: 4933403C17Rik; AI666536; Eaf1; ELL associated factor 1; ELL-associated factor 1
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Gene Symbols: Eaf1
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Molecular weight:
28,967 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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