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EAF1
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Belongs to the EAF family. Strongly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine and colon. Poorly expressed in thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of mouse Ortholog: 14|14 B |
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Cellular Component:
intercellular bridge; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; nucleus; super elongation complex; transcription elongation factor complex
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Molecular Function:
transcription elongation factor activity; transcription factor binding
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Biological Process:
positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription elongation by RNA polymerase II; transcription elongation by RNA polymerase II
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Reference #:
Q9D4C5
(UniProtKB)
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Alt. Names/Synonyms: 4933403C17Rik; AI666536; Eaf1; ELL associated factor 1; ELL-associated factor 1
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Gene Symbols: Eaf1
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Molecular weight:
28,967 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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