EAF1 Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Belongs to the EAF family. Strongly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine and colon. Poorly expressed in thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of mouse Ortholog: 14|14 B
Cellular Component:  intercellular bridge; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; nucleus; super elongation complex; transcription elongation factor complex
Molecular Function:  transcription elongation factor activity; transcription factor binding
Biological Process:  positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription elongation by RNA polymerase II; transcription elongation by RNA polymerase II
Reference #:  Q9D4C5 (UniProtKB)
Alt. Names/Synonyms: 4933403C17Rik; AI666536; Eaf1; ELL associated factor 1; ELL-associated factor 1
Gene Symbols: Eaf1
Molecular weight: 28,967 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein