CSIG Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. Belongs to the universal ribosomal protein uL1 family. Highly divergent. Expressed at high intensities in the heart, skeletal muscle, and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Translation
Chromosomal Location of mouse Ortholog: 16|16 A1
Cellular Component:  90S preribosome; nucleolus; nucleus
Molecular Function:  mRNA 3'-UTR binding; mRNA 5'-UTR binding; protein binding; RNA binding
Biological Process:  maturation of LSU-rRNA; regulation of apoptotic process; regulation of cellular senescence; regulation of protein localization
Reference #:  Q8BVY0 (UniProtKB)
Alt. Names/Synonyms: 2410005K20Rik; C76439; CSIG; pBK1; ribosomal L1 domain containing 1; Ribosomal L1 domain-containing protein 1; RL1D1; Rsl1d1
Gene Symbols: Rsl1d1
Molecular weight: 50,421 Da
Basal Isoelectric point: 9.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein