CPSF6 Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. Belongs to the RRM CPSF6/7 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 10|10 D2
Cellular Component:  cytoplasm; interchromatin granule; mRNA cleavage and polyadenylation specificity factor complex; mRNA cleavage factor complex; nuclear speck; nucleoplasm; nucleus; paraspeckles; perichromatin fibrils; ribonucleoprotein complex
Molecular Function:  exon-exon junction complex binding; mRNA binding; nucleic acid binding; ribosomal large subunit binding
Biological Process:  messenger ribonucleoprotein complex assembly; mRNA alternative polyadenylation; mRNA processing; positive regulation of RNA export from nucleus; pre-mRNA cleavage required for polyadenylation; protein heterotetramerization; protein tetramerization
Reference #:  Q6NVF9 (UniProtKB)
Alt. Names/Synonyms: 4733401N12Rik; AI256641; CFIM; CFIM6; CFIM68; cleavage and polyadenylation specific factor 6; Cleavage and polyadenylation specificity factor subunit 6; Cpsf6; HPBR; HPBRII-4; HPBRII-7
Gene Symbols: Cpsf6
Molecular weight: 59,153 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CPSF6

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene