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MAFA
Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds DNA as a homodimer (Probable). Interacts with NEUROD1, PCAF and PDX1. Up-regulated by glucose. Belongs to the bZIP family. Maf subfamily. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor |
| Chromosomal Location of Human Ortholog: 8q24.3 |
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Cellular Component:
nucleus
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Molecular Function:
DNA binding; DNA binding transcription factor activity; protein heterodimerization activity; protein homodimerization activity
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Biological Process:
insulin secretion; nitric oxide mediated signal transduction; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to glucose stimulus; transcription from RNA polymerase II promoter
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Disease: Insulinomatosis And Diabetes Mellitus
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Reference #:
Q8NHW3
(UniProtKB)
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Alt. Names/Synonyms: hMafA; MAFA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1; Transcription factor MafA; Transcription factor RIPE3b1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
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Gene Symbols: MAFA
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Molecular weight:
36,982 Da
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Basal Isoelectric point:
7.49
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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