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MAFA
Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence. Belongs to the bZIP family. Maf subfamily. Expressed in the islets of Langerhans (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor |
| Chromosomal Location of human Ortholog: 8q24.3 |
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Cellular Component:
chromatin; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
insulin secretion; nitric oxide mediated signal transduction; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to glucose
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Disease: Insulinomatosis And Diabetes Mellitus
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Reference #:
Q8NHW3
(UniProtKB)
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Alt. Names/Synonyms: hMafA; INSDM; MAF bZIP transcription factor A; MAFA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1; RIPE3b1 factor; Transcription factor MafA; Transcription factor RIPE3b1; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
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Gene Symbols: MAFA
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Molecular weight:
36,982 Da
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Basal Isoelectric point:
7.49
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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