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MAFA
Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence. Belongs to the bZIP family. Maf subfamily. Expressed in the islets of Langerhans (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor |
| Chromosomal Location of Human Ortholog: 8q24.3 |
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Cellular Component:
nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; protein homodimerization activity
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Biological Process:
insulin secretion; nitric oxide mediated signal transduction; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to glucose
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Disease: Insulinomatosis And Diabetes Mellitus
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Reference #:
Q8NHW3
(UniProtKB)
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Alt. Names/Synonyms: hMafA; MAFA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1; Transcription factor MafA; Transcription factor RIPE3b1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
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Gene Symbols: MAFA
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Molecular weight:
36,982 Da
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Basal Isoelectric point:
7.49
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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