MAFA Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence. Belongs to the bZIP family. Maf subfamily. Expressed in the islets of Langerhans (at protein level). Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor
Chromosomal Location of human Ortholog: 8q24.3
Cellular Component:  chromatin; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  insulin secretion; nitric oxide mediated signal transduction; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to glucose
Disease: Insulinomatosis And Diabetes Mellitus
Reference #:  Q8NHW3 (UniProtKB)
Alt. Names/Synonyms: hMafA; INSDM; MAF bZIP transcription factor A; MAFA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1; RIPE3b1 factor; Transcription factor MafA; Transcription factor RIPE3b1; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
Gene Symbols: MAFA
Molecular weight: 36,982 Da
Basal Isoelectric point: 7.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene