TAZ Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 3q25.1
Cellular Component:  cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus; plasma membrane; transcription regulator complex
Molecular Function:  protein binding; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity
Biological Process:  cilium assembly; glomerulus development; heart process; hippo signaling; kidney morphogenesis; mesenchymal cell differentiation; multicellular organism growth; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of transcription by RNA polymerase II; osteoblast differentiation; positive regulation of cell population proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of DNA-templated transcription; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of SMAD protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stem cell division; tissue homeostasis
Reference #:  Q9GZV5 (UniProtKB)
Alt. Names/Synonyms: DKFZp586I1419; FLJ27004; FLJ45718; TAZ; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; WWTR1
Gene Symbols: WWTR1
Molecular weight: 44,101 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein