TAZ
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. Note: This description may include information from UniProtKB.
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Protein type: Oncoprotein; Transcription, coactivator/corepressor |
Chromosomal Location of human Ortholog: 3q25.1 |
Cellular Component:
cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus; plasma membrane; transcription regulator complex
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Molecular Function:
protein binding; protein homodimerization activity; transcription coactivator activity; transcription corepressor activity
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Biological Process:
cilium assembly; glomerulus development; heart process; hippo signaling; kidney morphogenesis; mesenchymal cell differentiation; multicellular organism growth; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of transcription by RNA polymerase II; osteoblast differentiation; positive regulation of cell population proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of osteoblast differentiation; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase II; protein ubiquitination; regulation of DNA-templated transcription; regulation of metanephric nephron tubule epithelial cell differentiation; regulation of SMAD protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stem cell division; tissue homeostasis
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Reference #:
Q9GZV5
(UniProtKB)
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Alt. Names/Synonyms: DKFZp586I1419; FLJ27004; FLJ45718; TAZ; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; WWTR1
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Gene Symbols: WWTR1
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Molecular weight:
44,101 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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CST Pathways:
Hippo Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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