CBLL1 E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell adhesion; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 12|12 A2
Cellular Component:  cytoplasm; nuclear speck; nucleus; RNA N6-methyladenosine methyltransferase complex
Molecular Function:  identical protein binding; metal ion binding; protein binding; transferase activity; ubiquitin protein ligase activity
Biological Process:  cell-cell adhesion; mRNA methylation; multicellular organism development; negative regulation of cell adhesion; positive regulation of cell migration; positive regulation of endocytosis; protein ubiquitination
Reference #:  Q9JIY2 (UniProtKB)
Alt. Names/Synonyms: AI467391; c-Cbl-l; c-Cbl-like; c-Cbl-like protein 1; Casitas B-lineage lymphoma-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; Cbll1; E-cadherin binding protein E7; E3 ubiquitin-protein ligase Hakai; Hakai; RING-type E3 ubiquitin transferase Hakai
Gene Symbols: Cbll1
Molecular weight: 54,444 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
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CBLL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene