CBLL1 E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell adhesion; EC 6.3.2.-; EC; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 7q22.3
Cellular Component:  cytoplasm; cytosol; nuclear speck; nucleus; RNA N6-methyladenosine methyltransferase complex; ubiquitin ligase complex
Molecular Function:  identical protein binding; metal ion binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  cell-cell adhesion; mRNA methylation; negative regulation of cell adhesion; positive regulation of cell migration; positive regulation of endocytosis; protein ubiquitination; regulation of cell adhesion
Reference #:  Q75N03 (UniProtKB)
Alt. Names/Synonyms: c-Cbl-like protein 1; Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; Casitas B-lineage lymphoma-like; Casitas B-lineage lymphoma-transforming sequence-like protein 1; Cbl proto-oncogene like 1; Cbl proto-oncogene like 1, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; CBLL1; E-cadherin binding protein E7; E3 ubiquitin-protein ligase Hakai; FLJ23109; HAKAI; MGC163401; MGC163403; RING finger protein 188; RING-type E3 ubiquitin transferase Hakai; RNF188
Gene Symbols: CBLL1
Molecular weight: 54,519 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein