CDH1 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. Non-neural epithelial tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 8 D3|8 53.18 cM
Cellular Component:  actin cytoskeleton; adherens junction; apical junction complex; apical part of cell; axon; axon terminus; basolateral plasma membrane; catenin complex; cell junction; cell periphery; cell surface; cell-cell junction; cortical actin cytoskeleton; cytoplasm; cytoplasmic side of plasma membrane; endosome; flotillin complex; glutamatergic synapse; Golgi apparatus; lamellipodium; lateral loop; lateral plasma membrane; membrane; microvillus; node of Ranvier; perinuclear region of cytoplasm; plasma membrane; postsynapse; Schmidt-Lanterman incisure; trans-Golgi network
Molecular Function:  alpha-catenin binding; ankyrin binding; beta-catenin binding; cadherin binding; calcium ion binding; cell adhesion molecule binding; cytoskeletal protein binding; gamma-catenin binding; GTPase activating protein binding; identical protein binding; metal ion binding; molecular adaptor activity; protein binding; protein domain specific binding; protein phosphatase binding; protein tyrosine kinase binding
Biological Process:  actin cytoskeleton reorganization; adherens junction organization; bicellular tight junction assembly; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; canonical Wnt signaling pathway; cell adhesion; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell adhesion via plasma-membrane adhesion molecules; cellular response to amino acid stimulus; cellular response to indole-3-methanol; cellular response to lithium ion; cochlea development; decidualization; embryo implantation; epithelial cell morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; in utero embryonic development; intestinal epithelial cell development; negative regulation of axon extension; negative regulation of canonical Wnt signaling pathway; negative regulation of cell migration; negative regulation of cell-cell adhesion; negative regulation of epithelial cell proliferation; negative regulation of protein localization to plasma membrane; negative regulation of protein processing; positive regulation of cell-cell adhesion; positive regulation of DNA-templated transcription; positive regulation of protein import into nucleus; protein localization to plasma membrane; protein metabolic process; regulation of branching involved in salivary gland morphogenesis; regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of gene expression; regulation of neuron migration; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; regulation of protein localization; regulation of protein localization to cell surface; regulation of water loss via skin; salivary gland cavitation; sensory perception of sound; synapse assembly; trophectodermal cell differentiation; uterine epithelium development
Reference #:  P09803 (UniProtKB)
Alt. Names/Synonyms: AA960649; ARC-1; CADH1; cadherin 1; Cadherin-1; CD324; Cdh1; E-ca; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-cadh; E-cadherin; Eca; Ecad; Epithelial cadherin; L-C; L-CAM; MGC107495; OTTMUSP00000022465; Um; UVO; Uvomorulin
Gene Symbols: Cdh1
Molecular weight: 98,256 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene