|
CDH1
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. Non-neural epithelial tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 16q22.1 |
|
Cellular Component:
actin cytoskeleton; adherens junction; apical junction complex; catenin complex; cell junction; cortical actin cytoskeleton; cytoplasmic side of plasma membrane; endosome; extracellular region; flotillin complex; glutamatergic synapse; lamellipodium; lateral plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynapse; trans-Golgi network
|
|
Molecular Function:
ankyrin binding; beta-catenin binding; cadherin binding; calcium ion binding; cell adhesion molecule binding; gamma-catenin binding; GTPase activating protein binding; identical protein binding; protein binding; protein tyrosine kinase binding
|
|
Biological Process:
adherens junction organization; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell junction assembly; cellular response to indole-3-methanol; cellular response to lithium ion; homophilic cell adhesion via plasma membrane adhesion molecules; multicellular organism development; negative regulation of axon extension; negative regulation of cell migration; negative regulation of cell-cell adhesion; neuron projection development; pituitary gland development; positive regulation of DNA-templated transcription; positive regulation of protein import into nucleus; protein localization to plasma membrane; regulation of gene expression; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; response to Gram-positive bacterium; response to toxic substance; response to xenobiotic stimulus; synapse assembly
|
|
Disease: Blepharocheilodontic Syndrome 1; Breast Cancer; Endometrial Cancer; Gastric Cancer, Hereditary Diffuse; Ovarian Cancer
|
|
Reference #:
P12830
(UniProtKB)
|
|
Alt. Names/Synonyms: Arc-1; BCDS1; CADH1; Cadherin; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); Cadherin E; Cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell-CAM 120/80; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-cadherin; E-cadherin 1; ECAD; epididymis secretory sperm binding protein; Epithelial cadherin; LCAM; UVO; Uvomorulin
|
|
Gene Symbols: CDH1
|
|
Molecular weight:
97,456 Da
|
|
Basal Isoelectric point:
4.58
Predict pI for various phosphorylation states
|
|
CST Pathways:
Adherens Junction Dynamics
|
ErbB/HER Signaling
|
Wnt/ß-Catenin Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
