CDH1 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. Non-neural epithelial tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  actin cytoskeleton; apical junction complex; catenin complex; cell junction; cell-cell adherens junction; cytoplasmic side of plasma membrane; endosome; extracellular region; flotillin complex; glutamatergic synapse; integral component of membrane; lamellipodium; lateral plasma membrane; perinuclear region of cytoplasm; plasma membrane; postsynapse; trans-Golgi network
Molecular Function:  ankyrin binding; beta-catenin binding; cell adhesion molecule binding; gamma-catenin binding; GTPase activating protein binding; identical protein binding; protein binding
Biological Process:  adherens junction organization; cell-cell adhesion; cellular response to indole-3-methanol; cellular response to lithium ion; entry of bacterium into host cell; extracellular matrix organization; homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of cell migration; negative regulation of cell-cell adhesion; neuron projection development; pituitary gland development; positive regulation of protein import into nucleus; positive regulation of transcription, DNA-templated; protein localization to plasma membrane; regulation of gene expression; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; response to toxic substance
Disease: Blepharocheilodontic Syndrome 1; Breast Cancer; Endometrial Cancer; Gastric Cancer, Hereditary Diffuse; Ovarian Cancer; Prostate Cancer
Reference #:  P12830 (UniProtKB)
Alt. Names/Synonyms: Arc-1; CADH1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); Cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell-CAM 120/80; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; LCAM; UVO; Uvomorulin
Gene Symbols: CDH1
Molecular weight: 97,456 Da
Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene