NEK4 Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 3p21.1
Cellular Component:  ciliary basal body; ciliary plasm; ciliary rootlet; ciliary transition zone; cytoplasm; cytosol
Molecular Function:  ATP binding; manganese ion binding; protein serine/threonine kinase activity
Biological Process:  cell division; cellular response to DNA damage stimulus; mitotic cell cycle; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of cellular senescence; regulation of replicative cell aging; regulation of response to DNA damage stimulus
Reference #:  P51957 (UniProtKB)
Alt. Names/Synonyms: MGC33171; NEK4; Never in mitosis A-related kinase 4; NIMA (never in mitosis gene a)-related kinase 4; NIMA related kinase 4; NimA-related protein kinase 4; NRK2; pp12301; serine/threonine kinase 2; serine/threonine protein kinase-2; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase Nek4; serine/threonine-protein kinase Nek4 variant 2; Serine/threonine-protein kinase NRK2; STK2
Gene Symbols: NEK4
Molecular weight: 94,597 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein