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NEK4
a protein kinase of the NEK family. Highly conserved between the mouse and human and expressed at high levels in the testis. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of Human Ortholog: 3p21.1 |
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Cellular Component:
ciliary rootlet; cytoplasm; cytosol
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Molecular Function:
ATP binding; manganese ion binding; protein binding; protein serine/threonine kinase activity
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Biological Process:
activation of protein kinase activity; cell division; cellular response to DNA damage stimulus; mitotic cell cycle; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; regulation of cellular senescence; regulation of mitotic cell cycle; regulation of replicative cell aging; regulation of response to DNA damage stimulus
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Reference #:
P51957
(UniProtKB)
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Alt. Names/Synonyms: MGC33171; NEK4; Never in mitosis A-related kinase 4; NIMA (never in mitosis gene a)-related kinase 4; NimA-related protein kinase 4; NRK2; pp12301; serine/threonine kinase 2; serine/threonine protein kinase-2; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase Nek4; Serine/threonine-protein kinase NRK2; STK2
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Gene Symbols: NEK4
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Molecular weight:
94,597 Da
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Basal Isoelectric point:
8.04
Predict pI for various phosphorylation states
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