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NEK4
Protein kinase that seems to act exclusively upon threonine residues. Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 3p21.1 |
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Cellular Component:
ciliary basal body; ciliary plasm; ciliary rootlet; ciliary transition zone; cytoplasm; cytosol
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Molecular Function:
ATP binding; manganese ion binding; protein serine/threonine kinase activity
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Biological Process:
cell division; cellular response to DNA damage stimulus; mitotic cell cycle; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of cellular senescence; regulation of replicative cell aging; regulation of response to DNA damage stimulus
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Reference #:
P51957
(UniProtKB)
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Alt. Names/Synonyms: MGC33171; NEK4; Never in mitosis A-related kinase 4; NIMA (never in mitosis gene a)-related kinase 4; NIMA related kinase 4; NimA-related protein kinase 4; NRK2; pp12301; serine/threonine kinase 2; serine/threonine protein kinase-2; Serine/threonine-protein kinase 2; Serine/threonine-protein kinase Nek4; serine/threonine-protein kinase Nek4 variant 2; Serine/threonine-protein kinase NRK2; STK2
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Gene Symbols: NEK4
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Molecular weight:
94,597 Da
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Basal Isoelectric point:
8.04
Predict pI for various phosphorylation states
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