RCAN1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Interacts with RAF1. By calcium. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Belongs to the RCAN family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 16 C4|16 53.6 cM
Cellular Component:  cytoplasm; nucleus
Molecular Function:  calcium-dependent protein serine/threonine phosphatase regulator activity; identical protein binding; nucleic acid binding; protein binding
Biological Process:  calcineurin-NFAT signaling cascade; calcium-mediated signaling; locomotion involved in locomotory behavior; negative regulation of calcineurin-NFAT signaling cascade; regulation of calcineurin-NFAT signaling cascade; regulation of phosphoprotein phosphatase activity; response to ischemia; response to oxidative stress; short-term memory; skeletal muscle fiber development
Reference #:  Q9JHG6 (UniProtKB)
Alt. Names/Synonyms: 2410048A02Rik; AA408855; Adapt78; AI429645; AL024459; AV028423; calcineurin inhibitor; calcipressin 1; Calcipressin-1; CALP1L; CSP1; Down syndrome critical region homolog 1; Down syndrome critical region protein 1 homolog; DSC1; Dscr1; MCIP1; myocyte-enriched calcineurin interactin protein 1; Myocyte-enriched calcineurin-interacting protein 1; Rcan1; RCN1; Regulator of calcineurin 1
Gene Symbols: Rcan1
Molecular weight: 28,137 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
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RCAN1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene