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RCAN1
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor |
| Chromosomal Location of human Ortholog: 21q22.12 |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
calcium-dependent protein serine/threonine phosphatase regulator activity; nucleic acid binding; protein binding
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Biological Process:
calcineurin-NFAT signaling cascade; calcium-mediated signaling; locomotion involved in locomotory behavior; negative regulation of calcineurin-NFAT signaling cascade; regulation of phosphoprotein phosphatase activity; response to ischemia; response to oxidative stress; short-term memory; skeletal muscle fiber development
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Reference #:
P53805
(UniProtKB)
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Alt. Names/Synonyms: ADAPT78; Calcipressin-1; calcium and oxidant-inducible mRNA; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC1; DSCR1; MCIP1; modulatory calcineurin-interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; near DSCR proline-rich protein; RCAN1; RCN1; Regulator of calcineurin 1
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Gene Symbols: RCAN1
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Molecular weight:
28,079 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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