RCAN1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; protein binding
Biological Process:  blood circulation; calcineurin-NFAT signaling cascade; central nervous system development; negative regulation of calcineurin-NFAT signaling cascade; regulation of phosphoprotein phosphatase activity; regulation of transcription, DNA-templated; signal transduction
Reference #:  P53805 (UniProtKB)
Alt. Names/Synonyms: ADAPT78; Calcipressin-1; calcium and oxidant-inducible mRNA; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; DSC1; DSCR1; MCIP1; modulatory calcineurin-interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; near DSCR proline-rich protein; RCAN1; RCN1; Regulator of calcineurin 1
Gene Symbols: RCAN1
Molecular weight: 28,079 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein