SH3BP5
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Belongs to the SH3BP5 family. Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Chromosomal Location of rat Ortholog: 16p16 |
Cellular Component:
cytoplasm; cytoplasmic vesicle membrane; mitochondrion; nuclear body; nucleoplasm
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Molecular Function:
guanyl-nucleotide exchange factor activity; protein binding; protein kinase inhibitor activity; RNA methyltransferase activity; SH3 domain binding
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Biological Process:
intracellular signal transduction; JNK cascade; negative regulation of protein kinase activity; negative regulation of protein tyrosine kinase activity; RNA methylation; tRNA processing
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Reference #:
Q91Y80
(UniProtKB)
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Alt. Names/Synonyms: 3BP5; Sab; SH3 domain-binding protein 5; SH3-domain binding protein 5 (BTK-associated); SH3BP-5; Sh3bp5; Vascular endothelial cell-specific protein 18; Vesp18
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Gene Symbols: Sh3bp5
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Molecular weight:
50,829 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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