SH3BP5 Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. Belongs to the SH3BP5 family. Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of rat Ortholog: 16p16
Cellular Component:  cytoplasm; cytoplasmic vesicle membrane; mitochondrion; nuclear body; nucleoplasm
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; protein kinase inhibitor activity; RNA methyltransferase activity; SH3 domain binding
Biological Process:  intracellular signal transduction; JNK cascade; negative regulation of protein kinase activity; negative regulation of protein tyrosine kinase activity; RNA methylation; tRNA processing
Reference #:  Q91Y80 (UniProtKB)
Alt. Names/Synonyms: 3BP5; Sab; SH3 domain-binding protein 5; SH3-domain binding protein 5 (BTK-associated); SH3BP-5; Sh3bp5; Vascular endothelial cell-specific protein 18; Vesp18
Gene Symbols: Sh3bp5
Molecular weight: 50,829 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Select Structure to View Below

SH3BP5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene