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NF1
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Detected in brain, peripheral nerve, lung, colon and muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor |
| Chromosomal Location of Human Ortholog: 11 B5|11 46.74 cM |
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Cellular Component:
axon; cytoplasm; dendrite; membrane; neuron projection; nucleus; postsynaptic density; protein-containing complex
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Molecular Function:
GTPase activator activity; lipid binding; microtubule binding; phosphatidylcholine binding; phosphatidylethanolamine binding; protein binding; syndecan binding
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Biological Process:
actin cytoskeleton organization; adrenal gland development; amygdala development; artery morphogenesis; brain development; camera-type eye morphogenesis; cell communication; cellular response to heat; cerebral cortex development; cognition; collagen fibril organization; extracellular matrix organization; extrinsic apoptotic signaling pathway via death domain receptors; forebrain astrocyte development; forebrain morphogenesis; gamma-aminobutyric acid secretion, neurotransmission; glutamate secretion, neurotransmission; hair follicle maturation; heart development; liver development; MAPK cascade; metanephros development; myelination in peripheral nervous system; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of endothelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of neuroblast proliferation; negative regulation of neurotransmitter secretion; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of Rac protein signal transduction; negative regulation of Ras protein signal transduction; neural tube development; observational learning; osteoblast differentiation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of apoptotic process; positive regulation of endothelial cell proliferation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of GTPase activity; positive regulation of neuron apoptotic process; positive regulation of neuron projection development; Ras protein signal transduction; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of bone resorption; regulation of cell proliferation; regulation of cell-matrix adhesion; regulation of gene expression; regulation of glial cell differentiation; regulation of GTPase activity; regulation of long-term neuronal synaptic plasticity; regulation of long-term synaptic potentiation; regulation of MAPK cascade; regulation of neuron differentiation; regulation of synaptic transmission, GABAergic; response to hypoxia; Schwann cell development; signal transduction; skeletal muscle tissue development; smooth muscle tissue development; spinal cord development; sympathetic nervous system development; visual learning; wound healing
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Reference #:
Q04690
(UniProtKB)
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Alt. Names/Synonyms: AW494271; Dsk; Dsk9; E030030H24Rik; Mhdads; Mhdadsk9; neurofibromatosis 1; Neurofibromatosis-related protein NF-1; Neurofibromin; neurofibromin 1; Nf-; Nf-1; Nf1; OTTMUSP00000000223
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Gene Symbols: Nf1
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Molecular weight:
319,596 Da
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Basal Isoelectric point:
7.1
Predict pI for various phosphorylation states
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