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NF1
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Detected in brain, peripheral nerve, lung, colon and muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 11 B5|11 46.74 cM |
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Cellular Component:
axon; cytoplasm; dendrite; glutamatergic synapse; membrane; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
GTPase activator activity; lipid binding; microtubule binding; phosphatidylcholine binding; phosphatidylethanolamine binding; protein binding; syndecan binding
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Biological Process:
actin cytoskeleton organization; adrenal gland development; amygdala development; angiogenesis; apoptotic process; artery morphogenesis; astrocyte differentiation; brain development; camera-type eye morphogenesis; cell communication; cell migration; cell population proliferation; cellular response to heat; cerebral cortex development; cognition; collagen fibril organization; endothelial cell proliferation; extracellular matrix organization; extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; fibroblast proliferation; forebrain astrocyte development; forebrain morphogenesis; gamma-aminobutyric acid secretion, neurotransmission; glial cell proliferation; glutamate secretion, neurotransmission; hair follicle maturation; heart development; leukocyte apoptotic process; liver development; long-term synaptic potentiation; MAPK cascade; mast cell apoptotic process; mast cell proliferation; metanephros development; myelination in peripheral nervous system; myeloid cell apoptotic process; myeloid leukocyte migration; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of cell-matrix adhesion; negative regulation of endothelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of glial cell proliferation; negative regulation of leukocyte migration; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of mast cell proliferation; negative regulation of neuroblast proliferation; negative regulation of neurotransmitter secretion; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of Rac protein signal transduction; negative regulation of Ras protein signal transduction; negative regulation of Schwann cell migration; negative regulation of Schwann cell proliferation; negative regulation of stem cell proliferation; negative regulation of vascular associated smooth muscle cell migration; neural tube development; neuroblast proliferation; neuron apoptotic process; neurotransmitter secretion; observational learning; oligodendrocyte differentiation; osteoblast differentiation; osteoclast differentiation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of apoptotic process; positive regulation of endothelial cell proliferation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of GTPase activity; positive regulation of leukocyte apoptotic process; positive regulation of mast cell apoptotic process; positive regulation of myeloid cell apoptotic process; positive regulation of neuron apoptotic process; positive regulation of neuron projection development; positive regulation of vascular associated smooth muscle cell proliferation; postsynaptic signal transduction; protein import into nucleus; Rac protein signal transduction; Ras protein signal transduction; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of bone resorption; regulation of cell population proliferation; regulation of cell-matrix adhesion; regulation of ERK1 and ERK2 cascade; regulation of gene expression; regulation of glial cell differentiation; regulation of GTPase activity; regulation of long-term neuronal synaptic plasticity; regulation of long-term synaptic potentiation; regulation of MAPK cascade; regulation of modification of postsynaptic structure; regulation of neuron differentiation; regulation of postsynapse organization; regulation of synaptic transmission, GABAergic; response to hypoxia; Schwann cell development; Schwann cell migration; Schwann cell proliferation; skeletal muscle tissue development; smooth muscle tissue development; spinal cord development; stem cell proliferation; sympathetic nervous system development; vascular associated smooth muscle cell migration; vascular associated smooth muscle cell proliferation; visual learning; wound healing
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Reference #:
Q04690
(UniProtKB)
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Alt. Names/Synonyms: AW494271; Dsk; Dsk9; E030030H24Rik; Mhdads; Mhdadsk9; neurofibromatosis 1; Neurofibromatosis-related protein NF-1; Neurofibromin; neurofibromin 1; Nf-; Nf-1; Nf1; OTTMUSP00000000223
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Gene Symbols: Nf1
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Molecular weight:
319,596 Da
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Basal Isoelectric point:
7.1
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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