NF1 Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. Detected in brain, peripheral nerve, lung, colon and muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor
Chromosomal Location of Human Ortholog: 11 B5|11 46.74 cM
Cellular Component:  axon; cytoplasm; dendrite; membrane; neuron projection; nucleus; postsynaptic density; protein-containing complex
Molecular Function:  GTPase activator activity; lipid binding; microtubule binding; phosphatidylcholine binding; phosphatidylethanolamine binding; protein binding; syndecan binding
Biological Process:  actin cytoskeleton organization; adrenal gland development; amygdala development; artery morphogenesis; brain development; camera-type eye morphogenesis; cell communication; cellular response to heat; cerebral cortex development; cognition; collagen fibril organization; extracellular matrix organization; extrinsic apoptotic signaling pathway via death domain receptors; forebrain astrocyte development; forebrain morphogenesis; gamma-aminobutyric acid secretion, neurotransmission; glutamate secretion, neurotransmission; hair follicle maturation; heart development; liver development; MAPK cascade; metanephros development; myelination in peripheral nervous system; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of endothelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of neuroblast proliferation; negative regulation of neurotransmitter secretion; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of protein import into nucleus; negative regulation of protein kinase activity; negative regulation of Rac protein signal transduction; negative regulation of Ras protein signal transduction; neural tube development; observational learning; osteoblast differentiation; peripheral nervous system development; phosphatidylinositol 3-kinase signaling; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of apoptotic process; positive regulation of endothelial cell proliferation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of GTPase activity; positive regulation of neuron apoptotic process; positive regulation of neuron projection development; Ras protein signal transduction; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of bone resorption; regulation of cell proliferation; regulation of cell-matrix adhesion; regulation of gene expression; regulation of glial cell differentiation; regulation of GTPase activity; regulation of long-term neuronal synaptic plasticity; regulation of long-term synaptic potentiation; regulation of MAPK cascade; regulation of neuron differentiation; regulation of synaptic transmission, GABAergic; response to hypoxia; Schwann cell development; signal transduction; skeletal muscle tissue development; smooth muscle tissue development; spinal cord development; sympathetic nervous system development; visual learning; wound healing
Reference #:  Q04690 (UniProtKB)
Alt. Names/Synonyms: AW494271; Dsk; Dsk9; E030030H24Rik; Mhdads; Mhdadsk9; neurofibromatosis 1; Neurofibromatosis-related protein NF-1; Neurofibromin; neurofibromin 1; Nf-; Nf-1; Nf1; OTTMUSP00000000223
Gene Symbols: Nf1
Molecular weight: 319,596 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene