PLK4 Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.21; Kinase, protein; Nucleolus; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 4q28.1
Cellular Component:  centriole; centrosome; cleavage furrow; cytosol; deuterosome; nucleolus; XY body
Molecular Function:  ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity
Biological Process:  centriole replication; ciliary basal body-plasma membrane docking; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; G2/M transition of mitotic cell cycle; positive regulation of centriole replication; protein phosphorylation; regulation of G2/M transition of mitotic cell cycle; trophoblast giant cell differentiation
Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive, 2
Reference #:  O00444 (UniProtKB)
Alt. Names/Synonyms: MCCRP2; PLK-4; PLK4; polo like kinase 4; Polo-like kinase 4; polo-like kinase 4 (Drosophila); SAK; serine/threonine kinase 18; serine/threonine protein kinase SAK; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase Sak; Snk akin kinase; STK18
Gene Symbols: PLK4
Molecular weight: 108,972 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PLK4

Protein Structure Not Found.


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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein