TAB2 Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10|10 A1
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  K63-linked polyubiquitin modification-dependent protein binding; metal ion binding; protein binding
Biological Process:  heart development; positive regulation of protein kinase activity; response to lipopolysaccharide
Reference #:  Q99K90 (UniProtKB)
Alt. Names/Synonyms: 1110030N06Rik; A530078N03Rik; Kiaa0733; Map3k7ip2; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; mKIAA0733; TAB-2; Tab2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Gene Symbols: Tab2
Molecular weight: 76,442 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TAB2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene