TAB2 Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 6q25.1
Cellular Component:  cytosol; endosome membrane; nucleoplasm; plasma membrane
Molecular Function:  K63-linked polyubiquitin modification-dependent protein binding; metal ion binding; protein binding
Biological Process:  activation of MAPK activity; Fc-epsilon receptor signaling pathway; heart development; I-kappaB kinase/NF-kappaB signaling; interleukin-1-mediated signaling pathway; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase activity; response to lipopolysaccharide; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway
Disease: Congenital Heart Defects, Multiple Types, 2
Reference #:  Q9NYJ8 (UniProtKB)
Alt. Names/Synonyms: CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAB2; TAK1-binding protein 2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Gene Symbols: TAB2
Molecular weight: 76,494 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene