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GPIbB
Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium. Expressed in heart and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 16 A3|16 11.53 cM |
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Cellular Component:
glycoprotein Ib-IX-V complex; membrane; plasma membrane
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Molecular Function:
identical protein binding
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Biological Process:
blood coagulation; blood coagulation, intrinsic pathway; cell adhesion; hemostasis; megakaryocyte development; positive regulation of platelet activation; release of sequestered calcium ion into cytosol
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Reference #:
P56400
(UniProtKB)
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Alt. Names/Synonyms: CD42c; glycoprotein Ib, beta polypeptide; GP-Ib beta; Gp1bb; GPIb-beta; GPIbB; Platelet glycoprotein Ib beta chain
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Gene Symbols: Gp1bb
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Molecular weight:
21,763 Da
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Basal Isoelectric point:
10.51
Predict pI for various phosphorylation states
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