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IRF5
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Belongs to the IRF family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 6 A3.3|6 12.36 cM |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding
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Biological Process:
cellular response to virus; cytokine-mediated signaling pathway; defense response to virus; immune system process; inflammatory response; innate immune response; positive regulation of apoptotic process; positive regulation of cytokine production involved in immune response; positive regulation of transcription by RNA polymerase II; positive regulation of type I interferon production; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to muramyl dipeptide; response to peptidoglycan
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Reference #:
P56477
(UniProtKB)
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Alt. Names/Synonyms: AW491843; Interferon regulatory factor 5; interferon regulatory factor 5 bone marrow; IRF-5; Irf5; mir; mirf5
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Gene Symbols: Irf5
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Molecular weight:
56,005 Da
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Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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