IRF5 Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Belongs to the IRF family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 7q32.1
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  defense response to virus; interferon-gamma-mediated signaling pathway; positive regulation of apoptotic process; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of transcription by RNA polymerase II; response to muramyl dipeptide; response to peptidoglycan; type I interferon signaling pathway
Disease: Inflammatory Bowel Disease 14; Systemic Lupus Erythematosus, Susceptibility To, 10
Reference #:  Q13568 (UniProtKB)
Alt. Names/Synonyms: Interferon regulatory factor 5; IRF-5; IRF5; SLEB10
Gene Symbols: IRF5
Molecular weight: 56,044 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRF5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein