CCNH Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Belongs to the cyclin family. Cyclin C subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 13|13 C3
Cellular Component:  cyclin-dependent protein kinase activating kinase holoenzyme complex; nucleoplasm; nucleus; transcription factor TFIIH holo complex; transcription factor TFIIK complex
Molecular Function:  cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity
Biological Process:  cell cycle; positive regulation of transcription by RNA polymerase II; protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated
Reference #:  Q61458 (UniProtKB)
Alt. Names/Synonyms: 6330408H09Rik; AI661354; AV102684; AW538719; Ccnh; cyclin H; Cyclin-H
Gene Symbols: Ccnh
Molecular weight: 37,506 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CCNH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene