CCNH Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Belongs to the cyclin family. Cyclin C subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of mouse Ortholog: 13|13 C3
Cellular Component:  CAK-ERCC2 complex; cyclin-dependent protein kinase activating kinase holoenzyme complex; male germ cell nucleus; nucleoplasm; nucleus; transcription factor TFIIH core complex; transcription factor TFIIH holo complex; transcription factor TFIIK complex
Molecular Function:  cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; RNA polymerase II general transcription initiation factor activity
Biological Process:  cell cycle; DNA-templated transcription; protein stabilization; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription initiation at RNA polymerase II promoter
Reference #:  Q61458 (UniProtKB)
Alt. Names/Synonyms: 6330408H09Rik; AI661354; AV102684; AW538719; Ccnh; cyclin H; Cyclin-H
Gene Symbols: Ccnh
Molecular weight: 37,506 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CCNH

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein