CCNH Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Belongs to the cyclin family. Cyclin C subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 5q14.3
Cellular Component:  cyclin-dependent protein kinase activating kinase holoenzyme complex; nucleoplasm; transcription factor TFIIH holo complex
Molecular Function:  protein binding
Biological Process:  7-methylguanosine mRNA capping; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; nucleotide-excision repair, preincision complex assembly; positive regulation of transcription by RNA polymerase II; protein phosphorylation; protein stabilization; termination of RNA polymerase I transcription; transcription by RNA polymerase II; transcription elongation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair
Reference #:  P51946 (UniProtKB)
Alt. Names/Synonyms: CAK; CAK complex subunit; CCNH; CDK-activating kinase; CDK-activating kinase complex subunit; CycH; cyclin H; cyclin-dependent kinase-activating kinase; cyclin-dependent kinase-activating kinase complex subunit; Cyclin-H; MO15-associated protein; p34; p37
Gene Symbols: CCNH
Molecular weight: 37,643 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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