ASIC2 Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of rat Ortholog: 10q26
Cellular Component:  dendritic spine; membrane; neuron projection; neuronal cell body; plasma membrane; synapse
Molecular Function:  ligand-gated sodium channel activity; monoatomic cation channel activity; monoatomic ion channel activity; monoatomic ion gated channel activity; protein binding; voltage-gated sodium channel activity
Biological Process:  cellular response to acidic pH; cellular response to xenobiotic stimulus; detection of mechanical stimulus involved in sensory perception; establishment of localization in cell; monoatomic cation transmembrane transport; monoatomic cation transport; monoatomic ion transmembrane transport; negative regulation of apoptotic process; phototransduction; positive regulation of cation channel activity; positive regulation of synapse assembly; protein localization to synapse; regulation of membrane potential; regulation of monoatomic ion transmembrane transport; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; regulation of vasoconstriction; response to acidic pH; response to mechanical stimulus; sensory perception of sound; sensory perception of sour taste; sodium ion transmembrane transport; sodium ion transport; synapse assembly
Reference #:  Q62962 (UniProtKB)
Alt. Names/Synonyms: Accn1; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1 neuronal (degenerin) two different splice products: MDEG1 and MDEG2; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Asic2; ASIC2a/ASIC2b; BNaC1; BNC1; Brain sodium channel 1; degenerin; Mammalian degenerin homolog; MDEG; MDEG1; MDEG2
Gene Symbols: Accn1
Molecular weight: 57,739 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene