ASIC2 Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of mouse Ortholog: 11 B5|11 48.43 cM
Cellular Component:  dendritic spine; membrane; neuron projection; neuronal cell body; plasma membrane; synapse
Molecular Function:  ligand-gated sodium channel activity; monoatomic cation channel activity; monoatomic ion channel activity; monoatomic ion gated channel activity; protein binding; sodium channel activity; voltage-gated sodium channel activity
Biological Process:  cellular response to acidic pH; cellular response to xenobiotic stimulus; detection of mechanical stimulus involved in sensory perception; establishment of localization in cell; monoatomic cation transmembrane transport; monoatomic cation transport; monoatomic ion transmembrane transport; monoatomic ion transport; negative regulation of apoptotic process; phototransduction; positive regulation of cation channel activity; positive regulation of synapse assembly; protein localization to synapse; regulation of membrane potential; regulation of monoatomic ion transmembrane transport; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; regulation of vasoconstriction; response to acidic pH; response to mechanical stimulus; sensory perception of sound; sensory perception of sour taste; sodium ion transmembrane transport; sodium ion transport; synapse assembly
Reference #:  Q925H0 (UniProtKB)
Alt. Names/Synonyms: Acc; Accn1; ACIC2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Asic2; BNa; BNaC1; BNaC1a; BNC; BNC1; Brain sodium channel 1; degenerin; Mdeg; OTTMUSP00000000789; OTTMUSP00000000790
Gene Symbols: Asic2
Molecular weight: 57,739 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein