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ASIC2
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of mouse Ortholog: 11 B5|11 48.43 cM |
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Cellular Component:
dendritic spine; membrane; neuron projection; neuronal cell body; plasma membrane; synapse
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Molecular Function:
cation channel activity; ion channel activity; ion gated channel activity; ligand-gated sodium channel activity; protein binding; sodium channel activity; voltage-gated sodium channel activity
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Biological Process:
cation transmembrane transport; cation transport; cellular response to acidic pH; cellular response to xenobiotic stimulus; detection of mechanical stimulus involved in sensory perception; establishment of localization in cell; ion transmembrane transport; ion transport; negative regulation of apoptotic process; phototransduction; positive regulation of cation channel activity; positive regulation of synapse assembly; protein localization to synapse; regulation of ion transmembrane transport; regulation of membrane potential; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; regulation of vasoconstriction; response to acidic pH; response to mechanical stimulus; sensory perception of sound; sensory perception of sour taste; sodium ion transmembrane transport; sodium ion transport; synapse assembly
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Reference #:
Q925H0
(UniProtKB)
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Alt. Names/Synonyms: Acc; Accn1; ACIC2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Asic2; BNa; BNaC1; BNaC1a; BNC; BNC1; Brain sodium channel 1; degenerin; Mdeg; OTTMUSP00000000789; OTTMUSP00000000790
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Gene Symbols: Accn1
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Molecular weight:
57,739 Da
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Basal Isoelectric point:
5.08
Predict pI for various phosphorylation states
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