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ASIC2
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: 17q11.2-q12 |
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Cellular Component:
dendritic spine; neuronal cell body; plasma membrane
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Molecular Function:
ligand-gated sodium channel activity; protein binding; voltage-gated sodium channel activity
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Biological Process:
cellular response to acidic pH; cellular response to xenobiotic stimulus; central nervous system development; chemical synaptic transmission; detection of mechanical stimulus involved in sensory perception; establishment of localization in cell; inorganic cation transmembrane transport; negative regulation of apoptotic process; peripheral nervous system development; phototransduction; positive regulation of cation channel activity; positive regulation of synapse assembly; protein localization to synapse; regulation of membrane potential; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; regulation of vasoconstriction; sensory perception of sound; sensory perception of sour taste; sodium ion transmembrane transport; synapse assembly
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Reference #:
Q16515
(UniProtKB)
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Alt. Names/Synonyms: ACCN; ACCN1; acid sensing (proton gated) ion channel 2; acid sensing ion channel subunit 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; ASIC2; ASIC2a; BNAC1; BNC1; Brain sodium channel 1; degenerin; hBNaC1; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1
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Gene Symbols: ASIC2
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Molecular weight:
57,709 Da
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Basal Isoelectric point:
5.07
Predict pI for various phosphorylation states
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