TRAF2 a ubiquitin ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1- phosphate. Can homotrimer or heterotrimerize with TRAF1 and TRAF3 (via TRAF domains). Belongs to the TNF receptor-associated factor family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 9q34.3
Cellular Component:  CD40 receptor complex; cell cortex; cytoplasmic side of plasma membrane; cytosol; IRE1-TRAF2-ASK1 complex; membrane raft; nucleoplasm; plasma membrane signaling receptor complex; TRAF2-GSTP1 complex; tumor necrosis factor receptor superfamily complex; ubiquitin ligase complex; vesicle membrane
Molecular Function:  CD40 receptor binding; enzyme binding; identical protein binding; mitogen-activated protein kinase kinase kinase binding; molecular adaptor activity; protein binding; protein kinase binding; protein phosphatase binding; protein-containing complex binding; protein-macromolecule adaptor activity; sphingolipid binding; thioesterase binding; tumor necrosis factor binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  activation of NF-kappaB-inducing kinase activity; cellular response to nitric oxide; innate immune response; interleukin-17-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; mRNA stabilization; negative regulation of glial cell apoptotic process; negative regulation of neuron death; NIK/NF-kappaB signaling; positive regulation of DNA-binding transcription factor activity; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 production; positive regulation of JUN kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell cytokine production; positive regulation of tumor necrosis factor-mediated signaling pathway; programmed necrotic cell death; protein autoubiquitination; protein catabolic process; protein K63-linked ubiquitination; protein-containing complex assembly; regulation of apoptotic process; regulation of immunoglobulin production; regulation of protein-containing complex assembly; response to endoplasmic reticulum stress; signal transduction; signal transduction involved in regulation of gene expression; tumor necrosis factor-mediated signaling pathway
Reference #:  Q12933 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase TRAF2; MGC:45012; RING-type E3 ubiquitin transferase TRAF2; RNF117; TNF receptor associated factor 2; TNF receptor-associated factor 2; TRAF2; TRAP; TRAP3; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3
Gene Symbols: TRAF2
Molecular weight: 55,859 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein