PPP1R15B Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Belongs to the PPP1R15 family. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 1|1 E4
Cellular Component:  cytoplasm; endoplasmic reticulum; protein phosphatase type 1 complex
Molecular Function:  protein phosphatase regulator activity
Biological Process:  ER overload response; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of protein phosphorylation; peptidyl-serine dephosphorylation; positive regulation of phosphoprotein phosphatase activity; regulation of translation; regulation of translational initiation; response to endoplasmic reticulum stress; response to hydrogen peroxide; response to oxidative stress
Reference #:  Q8BFW3 (UniProtKB)
Alt. Names/Synonyms: 1810033K10Rik; AI606441; C530022L24Rik; Constitutive repressor of eIF2alpha phosphorylation; CReP; OTTMUSP00000024879; Ppp1r15b; PR15B; Protein phosphatase 1 regulatory subunit 15B; protein phosphatase 1, regulatory (inhibitor) subunit 15b
Gene Symbols: Ppp1r15b
Molecular weight: 77,712 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene