PPP1R15B Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Belongs to the PPP1R15 family. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  protein phosphatase type 1 complex
Molecular Function:  protein binding
Biological Process:  ER overload response; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of protein phosphorylation; peptidyl-serine dephosphorylation; response to hydrogen peroxide
Disease: Microcephaly, Short Stature, And Impaired Glucose Metabolism 2
Reference #:  Q5SWA1 (UniProtKB)
Alt. Names/Synonyms: CREP; FLJ14744; PPP1R15B; PR15B; Protein phosphatase 1 regulatory subunit 15B; protein phosphatase 1, regulatory (inhibitor) subunit 15B
Gene Symbols: PPP1R15B
Molecular weight: 79,152 Da
Basal Isoelectric point: 4.59  Predict pI for various phosphorylation states
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PPP1R15B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene