AS160 May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rab
Chromosomal Location of Human Ortholog: 14|14 E2.3
Cellular Component:  cytoplasm; cytosol; vesicle
Molecular Function:  GTPase activator activity; protein binding; Rab GTPase binding
Biological Process:  activation of GTPase activity; cellular response to insulin stimulus; intracellular protein transport; negative regulation of vesicle fusion; vesicle-mediated transport
Reference #:  Q8BYJ6 (UniProtKB)
Alt. Names/Synonyms: 5930406J04Rik; A930035N22; Akt substrate of 160 kDa; AS1; AS160; AV295684; Kiaa0603; TBC1 domain family member 4; TBC1 domain family, member 4; Tbc1d4; TBCD4
Gene Symbols: Tbc1d4
Molecular weight: 147,451 Da
Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene