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BTG2
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. Belongs to the BTG family. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of human Ortholog: 1q32.1 |
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Cellular Component:
cytoplasm; cytosol; nucleus
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Molecular Function:
protein binding; transcription corepressor activity
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Biological Process:
anterior/posterior pattern specification; associative learning; central nervous system neuron development; dentate gyrus development; DNA damage response; DNA repair; negative regulation of cell population proliferation; negative regulation of mitotic cell cycle; negative regulation of neuroblast proliferation; negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; negative regulation of translation; neuroblast proliferation; neuron projection development; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; protein methylation; response to electrical stimulus; response to mechanical stimulus; response to organic cyclic compound; response to peptide hormone; skeletal muscle cell differentiation
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Reference #:
P78543
(UniProtKB)
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Alt. Names/Synonyms: APRO1; B-cell translocation gene 2; BTG anti-proliferation factor 2; BTG family member 2; BTG family, member 2; BTG2; MGC126063; MGC126064; nerve growth factor-inducible anti-proliferative; NGF-inducible anti-proliferative protein PC3; PC3; pheochromacytoma cell-3; Protein BTG2; TIS21
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Gene Symbols: BTG2
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Molecular weight:
17,416 Da
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Basal Isoelectric point:
8.29
Predict pI for various phosphorylation states
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