S100A9 a calcium-binding regulatory protein of the S-100 family expressed by macrophages in acutely inflammated tissues and in chronic inflammations. May be an inhibitor of protein kinases. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells. Interacts with CEACAM3 in a calcium-dependent manner. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Cell development/differentiation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3 F1|3 39.91 cM
Cellular Component:  cell junction; cytoplasm; cytoskeleton; cytosol; extracellular region; extracellular space; membrane; nucleoplasm; plasma membrane
Molecular Function:  antioxidant activity; arachidonic acid binding; calcium ion binding; metal ion binding; microtubule binding; RAGE receptor binding; Toll-like receptor 4 binding; zinc ion binding
Biological Process:  actin cytoskeleton reorganization; activation of cysteine-type endopeptidase activity involved in apoptotic process; antimicrobial humoral immune response mediated by antimicrobial peptide; apoptotic process; astrocyte development; autocrine signaling; autophagy; chemotaxis; immune system process; inflammatory response; innate immune response; leukocyte chemotaxis; leukocyte migration involved in inflammatory response; modification of morphology or physiology of other organism; neutrophil aggregation; neutrophil chemotaxis; peptidyl-cysteine S-nitrosylation; peptidyl-cysteine S-trans-nitrosylation; positive regulation of blood coagulation; positive regulation of inflammatory response; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of neuron projection development; positive regulation of peptide secretion; regulation of inflammatory response; regulation of integrin biosynthetic process; regulation of translation
Reference #:  P31725 (UniProtKB)
Alt. Names/Synonyms: 60B8Ag; AW546964; BEE22; Cagb; Calgranulin-B; GAGB; L1Ag; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP-14; Mrp14; p14; Protein S100-A9; S100 calcium binding protein A9 (calgranulin B); S100 calcium-binding protein A9; S100 calcium-binding protein A9 (calgranulin B); S100a9; S10A9
Gene Symbols: S100a9
Molecular weight: 13,049 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene