neurogranin Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Belongs to the neurogranin family. In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component:  axon; cytosol; dendritic spine head; glutamatergic synapse; mitochondrial membrane; neuronal cell body; nucleus; postsynaptic density; postsynaptic membrane; trans-Golgi network transport vesicle membrane
Biological Process:  associative learning; nervous system development; positive regulation of long-term synaptic potentiation; postsynaptic modulation of chemical synaptic transmission; signal transduction; telencephalon development
Reference #:  Q92686 (UniProtKB)
Alt. Names/Synonyms: calmodulin-binding protein; hng; NEUG; NEUG(55-78); Neurogranin; neurogranin (protein kinase C substrate, RC3); Ng; NRGN; protein kinase C substrate; RC3
Gene Symbols: NRGN
Molecular weight: 7,618 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein