MPSK1 Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Ubiquitously expressed at very low levels. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, protein; MPSK subfamily; NAK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor)
Chromosomal Location of human Ortholog: 2q35
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; Golgi-associated vesicle; nucleoplasm; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process:  cellular response to transforming growth factor beta stimulus; positive regulation of transcription by RNA polymerase II; protein autophosphorylation
Reference #:  O75716 (UniProtKB)
Alt. Names/Synonyms: FLJ39635; hPSK; KRCT; MGC16211; MPSK; MPSK1; Myristoylated and palmitoylated serine/threonine-protein kinase; PKL12; protein kinase expressed in day 12 fetal liver; Protein kinase PKL12; PSK; serine/threonine kinase 16; Serine/threonine-protein kinase 16; STK16; TGF-beta-stimulated factor 1; TSF-1; TSF1; Tyrosine-protein kinase STK16
Gene Symbols: STK16
Molecular weight: 34,656 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein