RGS10 Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of mouse Ortholog: 7|7 F3
Cellular Component:  axon terminus; cytoplasm; cytosol; dendritic spine; neuronal cell body; nuclear body; nucleoplasm; nucleus
Molecular Function:  G-protein alpha-subunit binding; GTPase activator activity; protein binding
Biological Process:  G protein-coupled acetylcholine receptor signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway
Reference #:  Q9CQE5 (UniProtKB)
Alt. Names/Synonyms: 2310010N19Rik; MGC129414; OTTMUSP00000026329; Regulator of G-protein signaling 10; regulator of G-protein signalling 10; RGS10
Gene Symbols: Rgs10
Molecular weight: 21,151 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein