GNRHR Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Belongs to the G-protein coupled receptor 1 family. Pituitary, ovary, testis, breast and prostate but not in liver and spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4q13.2
Cellular Component:  integral component of plasma membrane; membrane; plasma membrane
Biological Process:  cellular response to gonadotropin-releasing hormone; G protein-coupled receptor signaling pathway; multicellular organism development
Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Reference #:  P30968 (UniProtKB)
Alt. Names/Synonyms: GnRH receptor; GnRH-R; GNRHR; GNRHR1; gonadotropin-releasing hormone (type 1) receptor 1; Gonadotropin-releasing hormone receptor; GRHR; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; LHRHR; LRHR; luliberin receptor; type I GnRH receptor
Gene Symbols: GNRHR
Molecular weight: 37,731 Da
Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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