LOK Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); SLK subfamily; STE group; STE20 family
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component:  plasma membrane; specific granule membrane
Molecular Function:  ATP binding; identical protein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process:  cell cycle; lymphocyte aggregation; neutrophil degranulation; protein autophosphorylation; protein phosphorylation; regulation of lymphocyte migration
Reference #:  O94804 (UniProtKB)
Alt. Names/Synonyms: LOK; Lymphocyte-oriented kinase; PRO2729; serine/threonine kinase 10; Serine/threonine-protein kinase 10; STK10
Gene Symbols: STK10
Molecular weight: 112,135 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
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LOK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene