LEPR iso6 Receptor for hormone LEP/leptin. On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production. Isoform A: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3. Isoform E: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. Belongs to the type I cytokine receptor family. Type 2 subfamily. Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218). Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 4 C6|4 46.96 cM
Cellular Component:  external side of plasma membrane; extracellular region; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; receptor complex
Molecular Function:  cytokine binding; cytokine receptor activity; identical protein binding; leptin receptor activity; peptide hormone binding; protein binding; protein-hormone receptor activity; transmembrane signaling receptor activity
Biological Process:  angiogenesis; bone growth; cholesterol metabolic process; eating behavior; energy homeostasis; glial cell proliferation; glucose homeostasis; glycogen metabolic process; leptin-mediated signaling pathway; negative regulation of autophagy; negative regulation of eating behavior; negative regulation of gluconeogenesis; negative regulation of hydrolase activity; negative regulation of locomotor rhythm; phagocytosis; positive regulation of cold-induced thermogenesis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of MAPK cascade; regulation of bone remodeling; regulation of feeding behavior; regulation of metabolic process; response to leptin; sexual reproduction; signal transduction; T cell differentiation
Reference #:  AAB95333 (GenPept)
Alt. Names/Synonyms: B219; db; diabetes; LEP-R; Lepr; LEPR iso6; Leprb; LEPROT; leptin receptor; leptin receptor gene-related protein; MGC105189; Modb1; OB receptor; OB-RGRP; obese-like; obl; Obr; OTTMUSP00000008795
Gene Symbols: Lepr
Molecular weight: 132,166 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
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LEPR iso6

Protein Structure Not Found.


Cross-references to other databases:  Entrez-Gene  |  GenPept  |  Ensembl Gene