AKAP12 Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component:  cell cortex; cytoplasm; cytoskeleton; cytosol; neuronal cell body; plasma membrane; Schaffer collateral - CA1 synapse
Molecular Function:  adenylate cyclase binding; protein binding; protein kinase A binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cellular response to interleukin-1; cellular response to tumor necrosis factor; G protein-coupled receptor signaling pathway; hepatic stellate cell activation; modulation of chemical synaptic transmission; negative regulation of vascular permeability; positive regulation of ERK1 and ERK2 cascade; positive regulation of hepatic stellate cell migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of oligodendrocyte apoptotic process; positive regulation of protein kinase A signaling; positive regulation of tumor necrosis factor biosynthetic process; positive regulation of tumor necrosis factor secretion; protein targeting; regulation of protein kinase A signaling; regulation of protein kinase C signaling; response to electrical stimulus; response to lipopolysaccharide
Reference #:  Q02952 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 12; A-kinase anchor protein 12; A-kinase anchor protein 250 kDa; A-kinase anchor protein, 250kDa; A-kinase anchoring protein 12; AKA12; AKAP 250; AKAP-12; AKAP12; AKAP250; DKFZp686M0430; DKFZp686O0331; FLJ20945; FLJ97621; Gravin; kinase scaffold protein gravin; Myasthenia gravis autoantigen; myasthenia gravis autoantigen gravin; Src-Suppressed C Kinase Substrate; SSeCKS
Gene Symbols: AKAP12
Molecular weight: 191,482 Da
Basal Isoelectric point: 4.37  Predict pI for various phosphorylation states
Select Structure to View Below

AKAP12

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein