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AKAP12
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 6q25.1 |
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Cellular Component:
cell cortex; cytoplasm; cytoskeleton; cytosol; neuronal cell body; plasma membrane; Schaffer collateral - CA1 synapse
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Molecular Function:
adenylate cyclase binding; calmodulin binding; protein binding; protein kinase A binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cellular response to interleukin-1; cellular response to tumor necrosis factor; G protein-coupled receptor signaling pathway; hepatic stellate cell activation; modulation of chemical synaptic transmission; negative regulation of vascular permeability; positive regulation of ERK1 and ERK2 cascade; positive regulation of hepatic stellate cell migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of oligodendrocyte apoptotic process; positive regulation of protein kinase A signaling; positive regulation of tumor necrosis factor production; regulation of protein kinase A signaling; regulation of protein kinase C signaling; response to electrical stimulus; response to lipopolysaccharide; signal transduction
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Reference #:
Q02952
(UniProtKB)
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Alt. Names/Synonyms: A kinase (PRKA) anchor protein 12; A-kinase anchor protein 12; A-kinase anchor protein 250 kDa; A-kinase anchor protein, 250kDa; A-kinase anchoring protein 12; AKA12; AKAP 250; AKAP-12; AKAP12; AKAP250; DKFZp686M0430; DKFZp686O0331; FLJ20945; FLJ97621; Gravin; kinase scaffold protein gravin; Myasthenia gravis autoantigen; myasthenia gravis autoantigen gravin; Src-Suppressed C Kinase Substrate; SSeCKS
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Gene Symbols: AKAP12
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Molecular weight:
191,482 Da
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Basal Isoelectric point:
4.37
Predict pI for various phosphorylation states
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