adrenodoxin Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Belongs to the adrenodoxin/putidaredoxin family. Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level). Note: This description may include information from UniProtKB.
Protein type: Mitochondrial
Chromosomal Location of mouse Ortholog: 9|9 A5.3
Cellular Component:  mitochondrial crista; mitochondrial matrix; mitochondrion
Molecular Function:  2 iron, 2 sulfur cluster binding; electron transfer activity; enzyme binding; iron ion binding; iron-sulfur cluster binding; metal ion binding
Biological Process:  cellular response to cAMP; cellular response to forskolin; cholesterol metabolic process; hormone biosynthetic process; lipid metabolic process; NADPH oxidation; oxidation-reduction process; positive regulation of oxidoreductase activity; regulation of catalytic activity; steroid biosynthetic process; steroid metabolic process
Reference #:  P46656 (UniProtKB)
Alt. Names/Synonyms: ADRE; Adrenal ferredoxin; adrenodoxin; Adrenodoxin, mitochondrial; ADX; Fdx1; ferredoxin 1; Ferredoxin-1
Gene Symbols: Fdx1
Molecular weight: 20,123 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene