PPP1CB is a catalytic subunit of protein phosphatase 1 (PP1), a ubiquitous cytosolic serine-threonine phosphatase. Composed a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5|5 B1
Cellular Component:  cytoplasm; cytosol; glycogen granule; nucleus; plasma membrane; protein phosphatase type 1 complex; PTW/PP1 phosphatase complex
Molecular Function:  hydrolase activity; metal ion binding; myosin-light-chain-phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding; protein serine/threonine phosphatase activity
Biological Process:  carbohydrate metabolic process; cell cycle; cell division; circadian regulation of gene expression; entrainment of circadian clock by photoperiod; glycogen metabolic process; protein dephosphorylation; regulation of cell adhesion; regulation of circadian rhythm; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process; rhythmic process
Reference #:  P62141 (UniProtKB)
Alt. Names/Synonyms: 1200010B19; OTTMUSP00000029005; PP-1B; PP1B; Ppp1cb; protein phosphatase 1, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Gene Symbols: Ppp1cb
Molecular weight: 37,187 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  Parkinson's Disease  |  Translation: eIF2
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene