SRPK2 a CMGC kinase of the SRPK family. Phosphorylates the SR (serine/arginine-rich domain) family of splicing factors. Localizes to the nucleus and the cytoplasm. Thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Highly expressed in brain and to a lesser extent other tissues. A second alternatively spliced transcript variant has been described, but its full length nature has not been determined. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); SRPK family
Chromosomal Location of Human Ortholog: 7q22.3
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
Molecular Function:  14-3-3 protein binding; ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  angiogenesis; cell differentiation; innate immune response; intracellular signal transduction; negative regulation of viral genome replication; nuclear speck organization; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of viral genome replication; protein phosphorylation; regulation of mRNA splicing, via spliceosome; RNA splicing; spliceosomal complex assembly
Reference #:  P78362 (UniProtKB)
Alt. Names/Synonyms: FLJ36101; H_RG152G17.1a; H_RG152G17.1b; serine kinase SRPK2; Serine/arginine-rich protein-specific kinase 2; Serine/threonine-protein kinase SRPK2; SFRS protein kinase 2; SFRSK2; SR-protein-specific kinase 2; SRPK2; SRSF protein kinase 2; WUGSC:H_RG152G17.1a
Gene Symbols: SRPK2
Molecular weight: 77,527 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
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SRPK2

Protein Structure Not Found.


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