CDC27 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC3/CDC27 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 17q21.32
Cellular Component:  anaphase-promoting complex; centrosome; cytoplasm; cytosol; mitotic spindle; nucleoplasm; nucleus; spindle
Molecular Function:  protein binding; protein phosphatase binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell division; metaphase/anaphase transition of mitotic cell cycle; protein K11-linked ubiquitination; protein ubiquitination; regulation of meiotic cell cycle; regulation of mitotic cell cycle
Reference #:  P30260 (UniProtKB)
Alt. Names/Synonyms: ANAPC3; anaphase promoting complex subunit 3; Anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3; APC3; CDC27; CDC27 homolog; CDC27Hs; cell division cycle 27; cell division cycle 27 homolog; cell division cycle 27 homolog (S. cerevisiae); cell division cycle protein 27; Cell division cycle protein 27 homolog; D0S1430E; D0S1430E, D17S978E; D17S978E; H-NUC; HNUC; NUC2; nuc2 homolog
Gene Symbols: CDC27
Molecular weight: 91,867 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein