APC4 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC4 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component:  anaphase-promoting complex; cytosol; nucleoplasm; nucleus
Molecular Function:  protein binding; protein phosphatase binding; ubiquitin-protein transferase activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; protein K11-linked ubiquitination; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process
Reference #:  Q9UJX5 (UniProtKB)
Alt. Names/Synonyms: ANAPC4; anaphase promoting complex subunit 4; Anaphase-promoting complex subunit 4; APC4; Cyclosome subunit 4
Gene Symbols: ANAPC4
Molecular weight: 92,116 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
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APC4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB